Seroquel is a medication of the new generation which has antipsychotic effect. It includes the main active ingredient Quetiapine.
Seroquel interacts with some receptors in a brain and neurons in the central nervous system. It contacts serotonin, histamine and dopamine receptors and regulates concentration of these chemical mediators in a brain.
In therapeutic doses, Seroquel doesn’t cause heavy side effects and is well tolerated. Its pharmacological action develops within several days and reaches a maximum in 1-2 weeks.
Seroquel reduces hallucinations, maniacal manifestations and psychomotor excitement, reduces symptoms of schizophrenia, psychoses, and restores emotional and mental balance.
What diseases is Seroquel prescribed for?
Seroquel is prescribed for the prevention and treatment of:
- Sharp and chronic psychoses, including schizophrenia
- Maniacal episodes
- Bipolar disorder
- Depressive and disturbing episodes at bipolar disorder
- Organic mental disorders
Seroquel is effective both at mono-therapy of mental disorders, and in a combination with other neuroleptics/ anti disturbing medications.
How to take Seriquel?
It is necessary to observe extra care and to follow the instruction on application. Incorrect dose can not only cause overdose, but also can worsen symptoms of a mental disorder.
Seroquel is produced in tablets for the oral use. The active period of action of a single dose lasts for 12 hours, and therefore it is necessary to take tablets 2 times per day.
Treatment of psychoses, including schizophrenia – it is necessary to begin treatment with the minimum daily dose of 50 mg (on 1 tablet Seroquel of 25 mg in the morning and in the evening). Within 4 days the dose is raised on 50-100 mg daily, to 300 mg of Seroquel per day.
Elimination of a bad attack of schizophrenia – it is necessary to begin treatment with the supporting Seroquel dose from 150 to 750 mg per day, depending on severity of symptoms of a disease.
Usually, the effective dose of Seroquel at maniacal episodes is 400 mg to 800 mg per day.
In process treatment a dosage of Seroquel can be corrected, depending on reaction of the patient to treatment and symptoms of a mental disorder.
During prolonged use of Seroquel in therapeutic doses, development of medicinal dependence is improbable. To avoid a cancellation syndrome, treatment needs to be stopped gradually, reducing a daily dose during 7-10 days.
Who is contraindicated to take Seroquel?
Researches on safety and efficiency of application of Seroquel in pregnant women weren’t carried out. Thus, Seroquel can be applied during pregnancy only if the expected advantage of application justifies potential risk.
It is necessary to stop breastfeeding if medication is taken during lactation.
Patients who are younger than 18 years are not recommended to take Seroquel, except for emergencies when other neuroleptics cause allergic reaction and can’t be used as antipsychotic means.
Side effects of Seroquel
Seroquel has the powerful oppressing effect on function of the central nervous system, and therefore during therapy there can be the following side effects: drowsiness, hypotension, dizziness, dyspepsia, sedation.
The body reacts to correction of a dose very well therefore it is possible to stop side effects by decrease a daily dose of Seroquel.
During therapy of Seroquel, increase of level of cholesterol in blood and serum triglycerides is possible. After the end of treatment, indicators of cholesterol return to normal.