Tramadol is an opioid analgesic which provides a central analgesic action and enhances the painful threshold. It acts through the spinal cord to the central nervous system and blocks the painful impulses. At the same time, Tramadol binds to the opioid receptors and lowers the sensitivity to pain.

Tramadol is considered the safest synthetic opioid analgesic. It does not cause a medical addiction, however a physiological addiction may happen during the prolonged use. Due to the appearance of the addiction to the medicine, the doses may be increased.

Besides a pain-relieving action, Tramadol provides an antitussive and sedative action. It calms the central nervous system and helps to easier tolerate pain.

The active ingredients of Tramadol are easily and quickly absorbed from the gastro-intestinal tract and do not affect the mucous membrane of the digestion system. The therapeutic effect is developed within 20 minutes but the length of the action of Tramadol is just 6 hours. Due to this, the pills should be often used to regularly control the pain symptoms.

Directions for the use

  • Painful syndrome of severe and middle intensity
  • Pain during malignant tumors
  • Arresting of pain during diagnostic or surgical interventions
  • Neurological pain

Contraindications for the use

  • Individual intolerance of the active ingredients of Tramadol
  • Acute alcohol intoxication
  • Intoxication by narcotics
  • Epilepsy
  • Renal failure
  • Liver failure
  • Age of under 14 years
  • Pregnancy Trimester 1

Who should take Tramadol carefully?

Tramadol is taken in 14 days after the cessation of the MAO inhibitors. The opioid analgesics are contraindicated during the use of the antidepressants of this group.

Pregnant women can take Tramadol during 2 and 3 term in the minimal dose only if the risk for a fetus is insignificant, and the treatment is prescribed by a qualified doctor. If using Tramadol causes the side effects, the use of the medicine is stopped.

Tramadol can slow down the speed of the psychomotor reactions, and therefore it is necessary to be careful during the treatment.

Instructions for the use

To arrest an acute pain, a pill of Tramadol 50-100 mg can be used. During chronic painful syndrome, the dosage regimen is individual. A patient is usually prescribed Tramadol in the minimal doses, and then the adjustment of the dose is made depending on the therapeutic effect.

  • Minimal single dose of Tramadol is 50 mg
  • Maximal single dose of Tramadol is 100 mg
  • Tramadol can be used every 6 hours regardless of the meals, with a full glass of water
  • It is contraindicated to take more than 400 mg of Tramadol per day

If the daily dose of Tramadol 400 mg does not help to effectively arrest acute pain, it is necessary to replace a medicine because of the developed resistance to the action of the analgesic.


In case of the overdose, Tramadol can cause side effects in the central nervous and respiratory systems: respiratory distress, apnea, vomiting, collapse, coma, and spasms. During these symptoms, do not take the pills and go to a doctor.

Side effects of Tramadol

Using Tramadol can cause side effects especially using high doses: retardation, sleepiness, weakness, nausea, and constipation.

If the use of the pills are suddenly stopped, a withdrawal syndrome may happen, and therefore the treatment is gradually stopped. In case of the appearance of severe side effects, it is necessary to see a doctor.


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