Product Description

Zyprexa is a medical product for the treatment and prevention of schizophrenia and acute psychosis. It contains the active ingredient Olanzapine which belongs to a group of atypical antipsychotics.

Zyprexa is the strongest representative of this medical group which acts quickly even during the severest forms of the mental disorders. It can be used by patients during acute attacks. If this medicine is ineffective, it is necessary to use conventional antipsychotics medications which have less intense therapeutic effect but help during chronic disorders.

The mechanism of the action of Zyprexa is related to the inhibition of the psychomotor agitation. Olanzapine blocks dopamine receptors of the brain, provides a sedative action and lowers an emotional superexcitation. There is also a reduction of the hostility and suspicion which are met in patients with schizophrenia

This medicine not only lowers the symptomatic of the acute mental disorders but also a risk of the relapse by restoring a chemical balance in the subcortical area of the brain.

A positive peculiarity of Zyprexa is a good tolerance and a fast onset of the effect. In 20-40 minutes after the use, the concentration of Olanzapine gains maximum in the blood plasma, and the pharmacological action begins within 2-3 hours. The active ingredients are excreted through liver, and therefore patients with chronic diseases of liver should be cautious and lower the daily dose.

Directions for the use

  • The acute form of schizophrenia
  • Delusional Disorder (exacerbation of chronic forms)
  • Bipolar affective psychosis
  • Affective disorders in schizophrenia
  • Zyprexa can be used to reduce hiccup, vomiting, and nausea, during acute mental disorders because it inhibits the activity of the D2-receptors of the vomiting center.

    How to take Zyprexa?

    The daily dose of Zyprexa is used once, at any time. It is desirable to take the medicine at the same time in order to produce and maintain a level of Olanzapine in the blood plasma on the same level.

  • In case of the acute condition of the mental disorders, Zyprexa is used in the dose of 10 mg per day
  • If the therapeutic effect is weak, the dose can be increased up to 20 mg of Zyprexa per day
  • The treatment is continued till the complete arresting of the symptoms of the acute mental disorder
  • To prevent schizophrenia or psychosis, Zyprexa can be used in the minimal daily dose of 5 mg within a long time.
  • Overdose

    It is very important to follow the dosage regimen and avoid taking Zyprexa more than 20 mg per day. If the daily dose is exceeded, the concentration of Olanzapine can increase the allowed concentration in the blood, and this will lead to the systemic side effects such as tachycardia, aggressiveness, confused speech, drowsiness, and respiratory depression.

    During the appearance of the overdose symptoms of Zyprexa, it is not recommended to cause vomiting. A stomach lavage is required and a symptomatic therapy is conducted under the supervision of a doctor.

    Side effects

    The side effects of Zyprexa can appear at any stage of the treatment but they quickly pass and are weak if the scheme of the treatment and overdose are followed. Patients often experience the following side effects during the use of Zyprexa: sleepiness, weight gain, decreased blood pressure, restlessness, anxiety, increase in prolactin levels and liver enzymes, and dizziness.

    The side effects of Zyprexa can be caused by the simultaneous use with Fluoxetine which enhances the concentration of Olanzapine in the blood by about 15-20%. The use of this medicine should be eliminated during the treatment. Olanzapine also increased an inhibiting action of ethanol to the central nervous system.


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